B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers?

Deep B cell depletion is delivering transformative clinical results in autoimmune diseases. Dealmakers are wagering on the best tools for the job.

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Authors and Affiliations

  1. London, UK

    Melanie Senior

  2. Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany

    Ricardo Grieshaber-Bouyer

  3. Universitätsklinikum Erlangen, Erlangen, Germany

    Ricardo Grieshaber-Bouyer

Authors

  1. Melanie Senior
  2. Ricardo Grieshaber-Bouyer

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Competing interests

R.G.-B. has research support or honoraria from AbbVie, Alfasigma, AstraZeneca, Bristol Myers Squibb, Candid Therapeutics, Cullinan Therapeutics, Epana Bio, Gilead, Kite, Johnson & Johnson, Kyverna Therapeutics, Lilly, Novartis, Pfizer, Sanofi, Xencor and UCB.

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Senior, M., Grieshaber-Bouyer, R. B cell depletion in autoimmune disease: in vivo CAR-T or T cell engagers?. Nat Biotechnol (2026). https://doi.org/10.1038/s41587-026-03069-5

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  • DOI: https://doi.org/10.1038/s41587-026-03069-5