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Credit: Dr. Pramod Tripathi, CC-BY 4.0 (
Nearly one-third of people with type 2 diabetes (T2D) in an Indian cohort achieved remission through an intensive lifestyle intervention program, according to a new study publishing October 22, 2025, in the open-access journal PLOS One by Pramod Tripathi of Freedom from Diabetes Clinic & Diabetes Research Foundation, India, and colleagues.
Type 2 diabetes affects more than 72 million people in India. While lifestyle interventions have shown promise for diabetes management in Western populations, limited data exists on their effectiveness in India, where genetic and lifestyle factors place the population at higher risk.
In the new study, researchers analyzed data from 2,384 adults with T2D who enrolled in a one-year online intensive lifestyle intervention program at the Freedom from Diabetes Clinic in India between May 2021 and August 2023. The intervention, provided by a six-member care team through a mobile application, included a personalized plant-based diet, structured physical activity, group therapy and individual psychological counseling, and medication management.
Overall, 744 participants (31.2%) achieved diabetes remission, defined as maintaining glycated hemoglobin (HbA1c) levels below 48 mmol/mol for at least three months without glucose-lowering medications. The remission group showed significantly greater improvements than the non-remission group in weight (8.5% vs. 5.2% reduction), body mass index (8.6% vs. 5.2% reduction), HbA1c (15.3% vs. 12.4% reduction), fasting insulin (26.6% vs. 11.4% reduction), and insulin resistance (37.3% vs. 19.7% reduction). People under 50 years of age, with higher BMI, no prior medication use, and a shorter duration of diabetes (PLOS One:
Citation: Tripathi P, Kadam N, Kathrikolly T, Tiwari D, Vyawahare A, Sharma B, et al. (2025) Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective analysis of an intensive lifestyle intervention program. PLoS One 20(10): e0333114.
Author countries: India
Funding: The author(s) received no specific funding for this work.
Journal
PLOS One
DOI
10.1371/journal.pone.0333114
Method of Research
Observational study
Subject of Research
People
Article Title
Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective analysis of an intensive lifestyle intervention program
Article Publication Date
22-Oct-2025
COI Statement
The authors have declared that no competing interests exist.
Media Contact
Hanna Abdallah
PLOS
Journal
PLOS One
DOI
10.1371/journal.pone.0333114
Method of Research
Observational study
Subject of Research
People
Article Title
Type 2 diabetes remission and its predictors in an Indian cohort: A retrospective analysis of an intensive lifestyle intervention program
Article Publication Date
22-Oct-2025
COI Statement
The authors have declared that no competing interests exist.
bu içeriği en az 2000 kelime olacak şekilde ve alt başlıklar ve madde içermiyecek şekilde ünlü bir science magazine için İngilizce olarak yeniden yaz. Teknik açıklamalar içersin ve viral olacak şekilde İngilizce yaz. Haber dışında başka bir şey içermesin. Haber içerisinde en az 12 paragraf ve her bir paragrafta da en az 50 kelime olsun. Cevapta sadece haber olsun. Ayrıca haberi yazdıktan sonra içerikten yararlanarak aşağıdaki başlıkların bilgisi var ise haberin altında doldur. Eğer yoksa bilgisi ilgili kısmı yazma.:
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Keywords
Tags: diabetes management in Indiadiabetes research foundationeffective diabetes treatment strategiesFreedom from Diabetes Clinichealth technology for diabetesIndian diabetes cohort studyintensive app-based lifestyle programlifestyle changes for diabeteslifestyle intervention programsPLOS One diabetes researchpredictors of diabetes remissionType 2 diabetes remission